The kidney is an important organ for Creatinine metabolism. The increase of creatinine indicates that renal function has been impaired. Serum creatinine is not only an important indicator of renal function, but also a key indicator of uremia. For this reason, patients pay special attention to the change of creatinine value.
Creatinine fluctuation may occur in most patients during treatment and after improvement. Most patients have a sudden rise in serum creatinine, usually caused by some acute factors. Without urgent dialysis, we should first find out the cause of acute kidney injury, actively treat it, and then check the renal function to see if dialysis is used. Early dialysis may lead to loss of residual renal function.
Usually these three reasons lead to creatinine elevation, generally do not need dialysis, which one are you?
1. Drug-induced creatinine elevation
In the course of nephropathy treatment, Kidney Friends often take a combination of drugs to treat multiple symptoms. Common such as glucocorticoids, immunosuppressive agents, diuretics, sartanopril drugs and so on, because of low immunity, antibiotics, cold drugs and other drugs will be used.
Some of these drugs have certain damage to the kidney, and some of the side effects of drugs can cause creatinine elevation. If antibiotics and cold medicines containing antipyretic and analgesic ingredients have definite nephrotoxicity, Kidney Patients generally do not recommend taking them for a long time. If they cause an increase in toxins in the body, they will lead to an increase in creatinine.
There are also sartan antihypertensive drugs, at the same time have the effect of reducing protein and delaying renal function.
However, these drugs have the effect of increasing creatinine. Generally, the increase of creatinine below 30% of the original creatinine is acceptable. If it exceeds this value, it is necessary to consider stopping the drug.
The creatinine elevation caused by these drugs is not caused by impaired kidney work and does not cause substantial damage. Therefore, without dialysis, doctors can be consulted to adjust the medication regimen.
2. Increased creatinine caused by infectious factors
Nephrotic patients have lower immunity than normal people, and take hormones and immunosuppressive drugs for a long time, so they are more likely to develop various infectious diseases. Common respiratory infections include colds, oral infections such as periodontitis, urinary infections such as kidney stones.
Infection can lead to an increase in inflammatory factors in the body, causing the already suppressed inflammatory response to relapse. The more active the inflammatory response, the more toxins in the body, the higher creatinine. If the source of infection can be found in time and treated accordingly to reduce inflammation, creatinine will generally recover slowly.
3. Overwork leads to creatinine elevation
Kidney has no good physical environment, and renal function can not be well restored. Some patients begin to work after their condition improves, which leads to abnormal fatigue, rapid decline of immunity, aggravation of proteinuria, further damage of renal function and increase of creatinine.
In addition, some bad eating habits can also lead to excessive kidney "fatigue", which is very harmful to kidney protection. Learn to balance kidney therapy and life.
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