Membranous Nephropathy can be seen at any age, but most patients have been diagnosed at the age of more than 30 years old, the average age of onset is 40 years old, the peak age of onset is 30-40 years old and 50-60 years old. What are the symptoms of membranous nephropathy? Membranous nephropathy is mostly slow onset and usually has no history of upper respiratory tract infection.
A few patients with membranous nephropathy present asymptomatic proteinuria. Most patients (70%-80%) have a large amount of proteinuria. The incubation period of membranous nephropathy in nephrotic syndrome is usually several weeks to several months, during which subepithelial deposits of the glomerulus gradually form but the increase of urinary protein excretion is not enough to form clinical nephrotic symptoms and cause the patient to suffer from nephropathy. The degree of attention was 80% of the patients had edema as the first symptom of nephrosis, and 20% were due to proteinuria.
What are the symptoms of membranous nephropathy? The urinary protein excretion of idiopathic membranous nephropathy usually ranges from 5 g to 10 g per day, or up to 20 g/d. Most of the urinary protein searches for non-selective proteinuria fluctuate greatly depending on the daily protein intake, body position, activity, and renal hemodynamics. There is no gross hematuria, and 50% of adults and most children develop microscopic hematuria.
Unlike many acute post-infectious nephritis, membranous nephropathy usually has no hypertension at the initial stage, but with the development of the disease, 30% - 50% of patients with membranous nephropathy have elevated blood pressure. Early onset of multiple normal renal function for weeks to months due to glomerular filtration decline, interstitial lesions and other factors can gradually appear renal insufficiency and uremia. Membranous nephropathy is liable to complicate with renal vein thrombosis, and 40% of the predisposing factors in China include low serum albumin (< 2.0-2.5 g/dl), excessive diuresis and long-term bed rest.
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